Asparaginase and treating diseases associated with asparagine dependence
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United States of America Patent
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Jun 9, 2015
Grant Date -
Sep 4, 2014
app pub date -
Oct 9, 2012
filing date -
Oct 10, 2011
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Abstract
Disclosed herein are polypeptides which exhibit asparaginase activity and little to no glutaminase activity. The polypeptides have sequences which correspond to W. succinogenes asparaginase, but have an amino acid residue other than proline at amino acid position 121. The polypeptides exhibit higher kinetic rates of asparaginase activity to glutaminase activity as compared to W. succinogenes asparaginase and Elspar®, an E. coli asparaginase.
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