Alpha-1 antitrypsin variant, preparation method thereof and use thereof

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United States of America Patent

PATENT NO 9051395
APP PUB NO 20140371160A1
SERIAL NO

14344468

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Abstract

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A novel alpha-1 antitrypsin variant, a method of preparing the same, and use thereof are provided. The alpha-1 antitrypsin variant has excellent stability in the body and maintains an inhibitory effect on elastase activities because the blood half-life (t1/2) and the area under blood drug concentration vs. time curve (AUC) are remarkably increased by adding an N-glycosylation site in animal cells through amino acid mutation between 1st and 25th positions of the N-terminus of alpha-1 antitrypsin. Therefore, the alpha-1 antitrypsin variant can be useful in preventing or treating alpha-1 antitrypsin deficiency.

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Patent OwnerAddress
ALTEOGEN INCDAEJEON 34054

International Classification(s)

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  • 2012 Application Filing Year
  • A61K Class
  • 11964 Applications Filed
  • 9694 Patents Issued To-Date
  • 81.03 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201220132014201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chung, Hye-Shin Daejeon, KR 13 95
Kim, Ji-Sun Daejeon, KR 67 560
Lee, Sang Mee Daejeon, KR 4 27
Park, Soon Jae Daejeon, KR 21 105

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  • 1 Citation Count
  • A61K Class
  • 31.06 % this patent is cited more than
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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges4055742610302931335621135761001 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0500100015002000250030003500400045005000550060006500700075008000

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