Alpha-1 antitrypsin variant, preparation method thereof and use thereof
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
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Jun 9, 2015
Grant Date -
Dec 18, 2014
app pub date -
Aug 13, 2012
filing date -
Sep 15, 2011
priority date (Note) -
In Force
status (Latency Note)
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Abstract
A novel alpha-1 antitrypsin variant, a method of preparing the same, and use thereof are provided. The alpha-1 antitrypsin variant has excellent stability in the body and maintains an inhibitory effect on elastase activities because the blood half-life (t1/2) and the area under blood drug concentration vs. time curve (AUC) are remarkably increased by adding an N-glycosylation site in animal cells through amino acid mutation between 1st and 25th positions of the N-terminus of alpha-1 antitrypsin. Therefore, the alpha-1 antitrypsin variant can be useful in preventing or treating alpha-1 antitrypsin deficiency.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
ALTEOGEN INC | DAEJEON 34054 |
International Classification(s)

- 2012 Application Filing Year
- A61K Class
- 11964 Applications Filed
- 9694 Patents Issued To-Date
- 81.03 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Chung, Hye-Shin | Daejeon, KR | 13 | 95 |
# of filed Patents : 13 Total Citations : 95 | |||
Kim, Ji-Sun | Daejeon, KR | 67 | 560 |
# of filed Patents : 67 Total Citations : 560 | |||
Lee, Sang Mee | Daejeon, KR | 4 | 27 |
# of filed Patents : 4 Total Citations : 27 | |||
Park, Soon Jae | Daejeon, KR | 21 | 105 |
# of filed Patents : 21 Total Citations : 105 |
Cited Art Landscape
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Patent Citation Ranking
- 1 Citation Count
- A61K Class
- 31.06 % this patent is cited more than
- 10 Age
Forward Cite Landscape
- No Forward Cites to Display

Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Dec 9, 2026 |
Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

Legal Events
Date | Code | Event | Description |
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Nov 11, 2022 | MAFP | MAINTENANCE FEE PAYMENT | free format text: PAYMENT OF MAINTENANCE FEE, 8TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2552); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY year of fee payment: 8 |
Nov 27, 2018 | MAFP | MAINTENANCE FEE PAYMENT | free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY year of fee payment: 4 |
Jun 09, 2015 | I | Issuance | |
May 20, 2015 | STCF | INFORMATION ON STATUS: PATENT GRANT | free format text: PATENTED CASE |
Dec 18, 2014 | P | Published | |
Mar 10, 2014 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:PARK, SOON JAE;CHUNG, HYE-SHIN;LEE, SANG MEE;AND OTHERS;REEL/FRAME:032416/0867 Owner name: ALTEOGEN, INC., KOREA, REPUBLIC OF Effective Date: Mar 10, 2014 |
Aug 13, 2012 | F | Filing | |
Sep 15, 2011 | PD | Priority Date |

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