Method for producing 4′-ethynyl d4T
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United States of America Patent
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Jun 9, 2015
Grant Date -
Nov 4, 2010
app pub date -
Dec 26, 2008
filing date -
Dec 27, 2007
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Abstract
Disclosed is a method for mass-producing 4′-ethynyl d4T (4′-ethynyl-2′,3′-didehydro-3′-deoxythymidine) by a simpler process at low cost. Specifically disclosed is a method for producing 4′-ethynyl d4T, which is characterized by comprising a step for introducing a triple bond-containing group into a furfuryl alcohol derivative or a levoglucosenone, by reacting the furfuryl alcohol derivative or levoglucosenone with a certain compound, and a step for reacting a compound represented by the formula (III), which is obtained by the aforementioned step, with thymine.
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