Pharmaceutical composition for treatment of corneal endothelial wounds containing angiogenin
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United States of America Patent
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Jun 9, 2015
Grant Date -
Mar 26, 2015
app pub date -
Sep 23, 2014
filing date -
Sep 23, 2013
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Abstract
Provided is a pharmaceutical composition for treating corneal endothelium wounds, the composition including angiogenin as an effective ingredient. The present invention relates to a new topical therapeutic use of angiogenin for treatment of corneal endothelium wounds, wherein the angiogenin that is generally known to be involved in angiogenesis activates a PI3K/Akt/eNOS pathway thereof in ocular corneal endothelium to increase migration and proliferation of corneal endothelial cells that are not capable of self-proliferation and to promote prevention and treatment of corneal endothelial cell wounds.
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