Compound accumulating in inflammatory site, diagnostic agent containing the compound in labeled state and its precursor compound for labeling

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United States of America Patent

PATENT NO 9044520
APP PUB NO 20120253010A1
SERIAL NO

13434722

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Abstract

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Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1):

description='In-line Formulae' end='lead'Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2  (1)description='In-line Formulae' end='tail'

    whereinin the formula (1),Z represents a protective group for an amino group;Y represents Met or Nle;X represents a spacer consisting of one or more of amino acid and/or synthetic organic compounds;n represents 1 or 0;m represents 1 or 0;k represents 1 or 0; andHalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.

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Patent Owner(s)

Patent OwnerAddress
KYOTO UNIVERSITYSAKYO-KU KYOTO-SHI KYOTO 606-8501

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kimura, Hiroyuki Kyoto, JP 355 4348
Ono, Masahiro Kyoto, JP 124 1511
Saji, Hideo Kyoto, JP 39 173
Seki, Ikuya Tokyo, JP 10 29

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