Method for preparing optically pure (+)-ambrisentan and (+)-darusentan
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United States of America Patent
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May 26, 2015
Grant Date -
Sep 4, 2014
app pub date -
Jul 1, 2011
filing date -
Jun 10, 2011
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Abstract
Disclosed is a method for preparing optically pure (+)-ambrisentan and (+)-darusentan, comprising: firstly catalyzing the asymmetric epoxidation of a β-unsaturated alkene using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to an epoxy compound ring-opening reaction and substitution reaction successively to obtain optically pure (+)-ambrisentan and (+)-darusentan.
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