Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution
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United States of America Patent
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May 26, 2015
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Apr 25, 2013
app pub date -
Jun 13, 2011
filing date -
Jun 14, 2010
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Abstract
Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent.
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