Tetrahydrotriazine compounds for treating diseases associated with AMPK activity

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United States of America Patent

PATENT NO 9035048
APP PUB NO 20110236317A1
SERIAL NO

12998848

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Abstract

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The invention relates to compounds of formula (I) wherein the radicals R1 to R6 have the meaning according to claim 1, and/or physiologically acceptable salts thereof, for the prophylactic or therapeutic treatment and/or monitoring of physiological and/or pathological conditions that are associated with the activity of AMP-activated protein kinase (AMPK). Another object of the invention concerns the use of said compounds for enhancing glucose homeostasis, improving podocytopathy and/or decreasing the production of reactive oxygen species (ROS). The invention also relates to a method for in-vitro diagnosing diabetic nephropathy and a method for screening compounds that reduce podocytopathy, in each case by applying synaptopodin as biomarker.

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Patent Owner(s)

Patent OwnerAddress
POXELIMMEUBLE LE SUNWAY 259/261 AVENUE JEAN JAURÈS LYON 69007

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cravo, Daniel Montesson, FR 33 169
Elbawab, Samer Bures sur Yvette, FR 11 23
Hallakou-Bozec, Sophie Montrouge, FR 19 64
Mesangeau, Didier Combs la Ville, FR 22 114

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