Modified gram-negative bacteria for use as vaccines
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United States of America Patent
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May 19, 2015
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Jun 5, 2014
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Sep 21, 2009
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Abstract
The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.
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