Method for native ligation of polypeptides

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United States of America Patent

PATENT NO 9029503
APP PUB NO 20120220721A1
SERIAL NO

13504054

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Abstract

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The invention mainly relates to a method for manufacturing a polypeptide of formula:

description='In-line Formulae' end='lead'X1—X″—X2  (III)description='In-line Formulae' end='tail'

X1 and X2 each representing a peptide fragment, and X″ representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula:

description='In-line Formulae' end='lead'X1—N(CH2CH2SH)2  (I)description='In-line Formulae' end='tail'

and a polypeptide of formula:

description='In-line Formulae' end='lead'H—X″—X2.  (II)description='In-line Formulae' end='tail'

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEPARIS FRA
INSTITUT PASTEUR DE LILLE59019 LILLE CEDEX
UNIVERSITE LILLE 2 - DROIT ET SANTE42 RUE PAUL DUEZ LILLE 59000
UNIVERSITE DE LILLE 1 - SCIENCES ET TECHNOLOGIESCITE SCIENTIFIQUE 59655 VILLENEUVE D'ASCQ CEDEX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dheur, Julien La Bassee, FR 2 5
Melnyk, Oleg Annoeullin, FR 15 37
Mhidia, Reda Mons en Baroeul, FR 2 5
Ollivier, Nathalie Roubaix, FR 6 11

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