Antagonists against TNFR1 and methods of use therefor
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United States of America Patent
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May 12, 2015
Grant Date -
Jan 24, 2013
app pub date -
Jul 13, 2011
filing date -
Jun 28, 2002
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Abstract
The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.
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