Antibodies against tropomyosin-related kinase B receptors
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United States of America Patent
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May 12, 2015
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Apr 24, 2014
app pub date -
May 18, 2012
filing date -
May 18, 2011
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Abstract
The invention relates to monoclonal antibodies directed to a particular part of tropomyosin-related kinase B receptor (TrkB) and hybridoma cell lines producing these. Fragments of these antibodies, in particular fragments representing complementarity determining regions (CDRs), and proteins comprising these, are useful in a method of treating cancer, pain, anorexia, anorexia nervosa and/or cachexia.
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