Methods of degrading or inhibiting botulinum neurotoxin using designer ubiquitin ligases
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United States of America Patent
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May 12, 2015
Grant Date -
Sep 26, 2013
app pub date -
Dec 26, 2012
filing date -
Jun 10, 2008
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Abstract
The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes a toxin binding domain that is specific for a toxin active fragment, wherein the toxin active fragment is an enzymatically active fragment of one or more toxins or toxin serotypes; and an E3-ligase domain that comprises an E3-ligase or polypeptide that facilitates E2-mediated ubiquitination of the toxin active fragment. In an embodiment, the composition further includes a delivery system that allow the designer ubiquitin ligase to enter the cell. The present invention further includes methods for treating an individual intoxicated with a toxin by administering the designer ubiquitin ligase of the present invention.
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