T cell receptor-deficient T cell compositions

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United States of America

PATENT NO 9028812
SERIAL NO

13502978

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Abstract

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The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.

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Patent Owner(s)

  • TRUSTEES OF DARTMOUTH COLLEGE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Sentman, Charles L West Lebanon, US 48 571

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