Anticancer combination of artemisinin-based drugs and other chemotherapeutic agents
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United States of America Patent
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May 5, 2015
Grant Date -
Oct 11, 2012
app pub date -
Dec 6, 2010
filing date -
Dec 23, 2009
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Abstract
The present invention relates to combinations between artemisinin-based potent anti-malarial agents, selected from the group consisting of ART, DHA and ARM, and a further chemotherapeutic drug selected from the group consisting of a camptothecin derivative, or a PARP-1 inhibitor, or an intercalating DNA agent, or an alkylating agent. Such combinations, showed medium to strong synergism in various models of cancer, in particular in NSCL.
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