Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof

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United States of America Patent

PATENT NO 9023318
APP PUB NO 20130217887A1
SERIAL NO

13849646

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Abstract

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Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITAT MUNSTERSCHLOSSPLATZ 2 MUENSTER 48149

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Breyholz, Hans-Joerg Muenster, DE 2 2
Chen, Gang Rancho Palos Verdes, US 944 8640
Faust, Andreas Billerbeck, DE 4 2
Gangadharmath, Umesh B Los Angeles, US 23 218
Haufe, Guenter Muenster, DE 3 2
Hermann, Sven Muenster, DE 7 66
Hugenberg, Verena Bersenbrueck, DE 2 2
Kasi, Dhanalakshmi Los Angeles, US 27 272
Kolb, Harmuth C Playa Del Ray, US 1 2
Kopka, Klaus Muenster, DE 30 159
Liu, Changhui Los Angeles, US 19 168
Schaefers, Michael Havixbeck, DE 4 2
Sinha, Anjana San Diego, US 18 217
Szardenings, Anna Katrin Torrance, US 25 383
Wagner, Stefan Muenster, DE 80 586
Walsh, Joseph C Pacific Palisades, US 124 2722
Wang, Eric San Diego, US 169 3986
Yu, Chul Los Angeles, US 21 189
Zhang, Wei Los Angeles, US 2625 19909

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