Vectors and methods for genetic immunization
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United States of America Patent
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Apr 28, 2015
Grant Date -
Jun 19, 2008
app pub date -
Jan 20, 2006
filing date -
Jan 20, 2005
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Abstract
Improved DNA vaccine plasmids are disclosed. The improved plasmids eliminate all extraneous sequences, and have superior eukaryotic expression, improved yield and stability during bacterial production, facilitate flexible targeting of antigens to various intracellular destinations, and novel RNA-based functionality. These vectors are utilized in novel immunization methods wherein combinations of immunostimulatory DNA vaccine plasmids that target antigens to various intracellular destinations are used to elicit improved immune response.
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