Engineering microbes for efficient production of chemicals
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United States of America Patent
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Apr 28, 2015
Grant Date -
Aug 30, 2012
app pub date -
Nov 17, 2010
filing date -
Nov 18, 2009
priority date (Note) -
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Abstract
This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.
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