HIV-1 latency model for high throughput screening
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United States of America Patent
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Apr 28, 2015
Grant Date -
Feb 14, 2013
app pub date -
Jul 17, 2012
filing date -
Dec 5, 2005
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Abstract
Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I derived vector pro virus, which upon activation expresses a marker for late viral gene expression due to the insertion of the marker gene in the position of HIV-I envelope.
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