High affinity human antibodies to human cytomegalovirus (CMV) gB protein
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United States of America Patent
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Apr 28, 2015
Grant Date -
Jan 26, 2012
app pub date -
Jun 16, 2011
filing date -
Jun 16, 2010
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Abstract
Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
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