Light activated composite tissue adhesives
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United States of America Patent
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Apr 14, 2015
Grant Date -
May 26, 2011
app pub date -
Nov 10, 2010
filing date -
Nov 10, 2009
priority date (Note) -
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status (Latency Note)
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Abstract
A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions. These composites have also been found to be strong tissue adheives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C08H:DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C09H:PREPARATION OF GLUE OR GELATINE
- A61F:FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES....
- A61D:VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METH....
- A61B:DIAGNOSIS; SURGERY; IDENTIFICATION
- A61P:THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDI....
- C07K:PEPTIDES
- A61L:METHODS OR APPARATUS FOR STERILISING MATERIALS OR ....
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