Modified pyrazine derivatives and uses thereof
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United States of America Patent
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Apr 14, 2015
Grant Date -
Jul 3, 2014
app pub date -
Mar 4, 2014
filing date -
Dec 17, 2008
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Abstract
Provided herein are compounds, preparations and formulations comprising pyrazine derivatives having multiple poly(ethylene glycol) containing substituents. Many of the compounds disclosed herein are excretable by the renal system of a subject or patient and are useful for visualizing the renal system of a subject or patient. Upon excitation by electromagnetic radiation, a number of the compounds disclosed herein exhibit luminescence and are externally detectable when present in the body fluid of a patient or subject. Also provided herein are methods for visualizing the renal system of a subject or patient.
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