Controlled release compositions comprising a combination of isosorbide dinitrate and hydralazine hydrochloride
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United States of America Patent
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Mar 31, 2015
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app pub date -
Sep 7, 2012
filing date -
Oct 31, 2005
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Abstract
The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate and hydralazine hydrochloride can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.
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