Immunogenic lipopeptides comprising T-helper and cytotoxic T-lymphocyte (CTL) epitopes
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United States of America Patent
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Mar 24, 2015
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Nov 17, 2011
app pub date -
Oct 8, 2010
filing date -
Aug 12, 2002
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Abstract
The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and CTL epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular CTL epitopes. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the CTL epitope.
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