Cancer targeting using carbonic anhydrase isoform IX inhibitors
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United States of America Patent
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Mar 17, 2015
Grant Date -
Oct 17, 2013
app pub date -
Dec 21, 2011
filing date -
Dec 24, 2010
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Abstract
The present invention concerns novel carbonic anhydrase IX inhibitors comprising a nitroimidazole moiety and their use in therapy of hypoxic conditions, in particular cancer treatment, especially chemotherapy and radiotherapy. The compounds of the invention have an increased specificity for the carbonic anhydrase IX enzyme compared to the art. The present invention relates to novel nitroimidazole derivates represented by formula (1).
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