5-fluoro-3-phenyl-2[1-(9H-purin-6-ylamino)propyl]-3H-quinazolin-4-one and 6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)ethyl]-3H-quinazolin-4-one as inhibitors of human phosphatidylinositol 3-kinase delta

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United States of America Patent

PATENT NO 8980901
SERIAL NO

14049163

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Abstract

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Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed. Exemplary compounds disclosed in this application are shown below:

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Patent Owner(s)

Patent OwnerAddress
GILEAD SCIENCES INC333 LAKESIDE DR FOSTER CITY CA 94404

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fowler, Kerry W Seattle, US 53 940
Huang, Danwen Bellevue, US 21 685
Kesicki, Edward A Bothell, US 73 2351
Oliver, Amy Bothell, US 40 2073
Ooi, Hua Chee Mill Creek, US 15 656
Puri, Kamal Deep Lynnwood, US 10 273
Ruan, Fuqiang Bellevue, US 33 718
Treiberg, Jennifer Redmond, US 27 2028

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