Minor groove binder (MGB)-oligonucleotide miRNA antagonists
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United States of America Patent
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Mar 17, 2015
Grant Date -
Sep 27, 2012
app pub date -
Jun 7, 2012
filing date -
Nov 25, 2009
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Abstract
Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.
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