Enzymatic degradation of lipid A fatty acids of bacterial LPS
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United States of America Patent
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Mar 10, 2015
Grant Date -
Dec 25, 2008
app pub date -
Nov 23, 2006
filing date -
Nov 23, 2005
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Abstract
Novel enzymes, processes and antigenic structures useful in producing vaccines and compounds useful in combating gram-negative bacteria are described. Enzymes were isolated from the slime mold Dictyostelium discoideum and used to specifically degrade lipopolysaccharide (LPS). Enzymatic degradation permits residues of the LPS molecule, including immunogenic epitopes of the core oligosaccharide portion of the LPS, to remain unmodified during this enzymatic removal of fatty acids from the lipid A region of the LPS molecule.
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