Amide based glucagon and superfamily peptide prodrugs
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United States of America Patent
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Mar 3, 2015
Grant Date -
Nov 24, 2011
app pub date -
Dec 18, 2009
filing date -
Dec 19, 2008
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Abstract
Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
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