Large scale and stable production of human FVIII in the human cell line Sk-Hep-1

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United States of America Patent

PATENT NO 8969041
SERIAL NO

13981446

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Abstract

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The present invention refers to: 1) the method for the production of recombinant FVIII in human Sk-Hep-1 cells, comprising von Willebrand Factor (vWF) and 2) the population of human cells transduced with a vector encoding the clotting protein (FVIII). The technical object of the present patent application is intended for the cultivation of human cells in suspension and in adhesion and isolation of the culture medium containing the desired protein. The object of the invention is to provide a safer product (free of potential human viruses), that is cheaper and more stable, by means of a method that provides sufficient amounts and on industrial scale to meet the National demand.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSIDADE DE SAO PAULO-USPRUA DA PRAÇA DO RELÓGIO 109 CIDADE UNIVERSITÁRIA "ARMANDO SALLES OLIVEIRA" BUTANTÃ SÃO PAULO 05508-900
FUNDACÃO HEMOCENTRO DE RIBEIRÃO PRETORUA TENENTE CATÃO ROXO 2501 BAIRRO MONTE ALEGRE RIBEIRÃO PRETO 14051-140

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Covas, Dimas Tadeu Ribeirao Preto, BR 5 9
De, Souza Russo Carbolante Elisa Maria Ribeirao Preto, BR 1 2
Picanco, E Castro Virginia Ribeirao Preto, BR 1 2
Swiech, Kamilla Ribeirao Preto, BR 3 3

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