Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use
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United States of America Patent
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Mar 3, 2015
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Oct 3, 2013
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Mar 14, 2013
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Mar 23, 2011
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Abstract
3-alkynyl inosine analogs and their uses as universal bases are provided. The inosine analogs can be incorporated into nucleic acid primers and probes. They do not significantly destabilize nucleic acid duplexes. As a result, the novel nucleic acid primers and probes incorporating the inosine analogs can be used in a variety of methods. The analogs function unexpectedly well as universal bases. Not only do they stabilize duplexes substantially more than hypoxanthine opposite A, C, T, and G but they are also recognized in primers by polymerases, allowing efficient amplification.
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