Gene delivery of OCT4 and SirT1 and pharmaceutical compositions thereof
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United States of America Patent
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Feb 24, 2015
Grant Date -
Feb 28, 2013
app pub date -
Aug 31, 2012
filing date -
Aug 31, 2011
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Abstract
The present invention provides a method for decreasing the level of methylation of Oct4 promoter in a target cell, comprising transfecting the target cell with the combination of Oct4 cDNA and SirT1 cDNA. The invention also provides a method for inducing cytoprotective responses of a target cell, comprising transfecting the target cell with the combination of Oct4 cDNA and SirT1 cDNA. The invention further provides a pharmaceutical composition comprising Oct4 cDNA and SirT1 cDNA, or a polynucleotide comprising Oct4 cDNA and SirT1 cDNA.
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