FGF-2 variants having N-terminal deletions and increased receptor selectivity and uses thereof
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United States of America Patent
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Feb 24, 2015
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Oct 7, 2007
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Sep 28, 2006
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Abstract
The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In particular, the invention relates to isolated FGF2 and FGF4 polypeptides that include a truncated N-terminus and optionally N-terminal amino acid substitutions. The present invention provides polypeptides, nucleic acids encoding the polypeptides, compositions of the same and methods for use thereof.
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