Induced pluripotent stem cells produced with a connexin inhibitor and a TGF-β signaling inhibitor
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United States of America Patent
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Feb 17, 2015
Grant Date -
Aug 23, 2012
app pub date -
Dec 27, 2011
filing date -
Dec 27, 2010
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Abstract
The present invention provides a method for producing iPS cells, comprising reacting cells with at least one connexin inhibitor and at least one TGFβ signaling inhibitor; iPS cells comprising at least one connexin inhibitor; an iPS cell inducer comprising at least one inhibitor selected from the group consisting of connexin inhibitors and TGFβ signaling inhibitors; a medium for inducing iPS cells, comprising at least one inhibitor selected from the group consisting of connexin inhibitors and TGFβ signaling inhibitors; and a kit for inducing iPS cells, comprising at least one inhibitor selected from the group consisting of connexin inhibitors and TGFβ signaling inhibitors.
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