Peptide associated with rheumatic fever (PARF) and its use as a diagnostic marker
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United States of America Patent
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Feb 17, 2015
Grant Date -
Jun 17, 2010
app pub date -
Jun 1, 2007
filing date -
Jun 6, 2006
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Abstract
The present invention relates to a streptococcal octapeptide AXYLXXLN, and preferably to the octapeptide AXYLZZLN, designated as peptide associated with rheumatic fever (PARF) that, through its interaction with human collagen, plays a crucial role in the pathogenesis of rheumatic fever. PARF therefore represents a marker for rheumatic fever associated strains and provides a target for therapies, and in particular preventive therapies.
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