Activated sialic acid derivatives for protein derivatisation and conjugation
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United States of America Patent
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Feb 10, 2015
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Jan 24, 2014
filing date -
Feb 23, 2005
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Abstract
Derivatives of PSAs are synthesised, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.
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