Glucagon-like peptide-1 analogues and uses thereof
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United States of America Patent
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Feb 10, 2015
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Feb 28, 2013
app pub date -
Apr 29, 2011
filing date -
Apr 27, 2010
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Abstract
Provided is a glucagon-like peptide-1 (GLP-1) analog shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analog has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analog is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analog in conquering blood sugar.
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