Lentiviral vectors containing an MHC class I promoter
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United States of America Patent
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Feb 10, 2015
Grant Date -
May 1, 2014
app pub date -
Apr 30, 2013
filing date -
May 23, 2012
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Abstract
The present invention relates to the insertion of a promoter sequence from an MHC class I gene promoter into a lentiviral vector in order to direct the transcription of a transgene, which preferably encodes an immunogenic polypeptide to be expressed in a mammalian cell host, preferably APC (DCs). The invention encompasses these vectors, methods of making the vectors, and methods of using them, including medicinal uses.
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