Variant immunoglobulins with improved manufacturability
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United States of America Patent
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Feb 10, 2015
Grant Date -
Jun 14, 2012
app pub date -
Aug 20, 2010
filing date -
Aug 21, 2009
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Abstract
This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.
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