Method for producing synthetic amylospheroid
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United States of America Patent
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Feb 3, 2015
Grant Date -
Nov 27, 2014
app pub date -
Dec 18, 2012
filing date -
Dec 22, 2011
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Abstract
Provided is a method for producing synthetic amylospheroids efficiently, the method including agitating a liquid containing amyloid β-peptides in the presence of a plasticizer. Amylospheroid refers to an assembly of amyloid β-peptides that selectively can induce cell death of functionally mature neurons. Amylospheroid is considered to play a central role in the development of Alzheimer's disease and dementia with Lewy bodies.
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