Agent for suppressing expression of dominant allele
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United States of America Patent
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Feb 3, 2015
Grant Date -
Apr 11, 2013
app pub date -
Jun 17, 2011
filing date -
Jun 18, 2010
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Abstract
An agent for selectively suppressing the expression of a dominant allele while allowing expression of wild-type or desired alleles and methods for using the agent are described. The RNAi agent has a structure obtained by assigning a dominant point mutation in the targeted allele as a standard point, setting a base length from the standard point to the 5′ end to a predetermined length, and introducing one mismatch base differing from the target sequence to a predetermined position downstream from the standard point.
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