Methods for improved DNA release from binding substrates and/or decreasing PCR inhibition in pathogen detection
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United States of America Patent
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Feb 3, 2015
Grant Date -
Sep 20, 2012
app pub date -
Mar 14, 2012
filing date -
Mar 15, 2011
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Abstract
Disclosed herein are processes for collecting nucleic acids from particulate samples. One embodiment disclosed herein relates to the use of ultrasonic energy to simultaneously shear large nucleic acid molecules and large particulates to very small sizes prior to or during a chemical binding step to a nucleic acid binding surface. Another embodiment involves crushing the nucleic acid binding surface prior to eluting the bound nucleic acid molecules to enable better wetting of the nucleic acid binding surface and easier diffusion of bound nucleic acid molecules out of the nucleic acid binding surface.
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