Process for the preparation of lasofoxifene tartrate
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United States of America Patent
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Jan 20, 2015
Grant Date -
Feb 23, 2012
app pub date -
Apr 27, 2010
filing date -
Apr 29, 2009
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Abstract
A solid crystalline form of 1-(2-[4-(6-methoxy-3,4-dihydronaphthalene-1-y) phenoxy]ethyl)pyrrolidine, and a preparing process thereof are provided. The aforesaid compound is a key intermediate in the synthesis of lasofoxifene. A process for preparing lasofoxifene, a process for purifying lasofoxifene tartrate, and a crystalline form of lasofoxifene tartrate are also provided.
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