Methods and compositions for oral administration of protein and peptide therapeutic agents
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United States of America Patent
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Jan 20, 2015
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app pub date -
Jan 8, 2009
filing date -
Jan 8, 2008
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Abstract
The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
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