Fusion proteins and methods of use
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United States of America Patent
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Jan 13, 2015
Grant Date -
Mar 6, 2014
app pub date -
Jun 28, 2013
filing date -
Aug 28, 2012
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Abstract
Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin.
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