Compounds for the inhibition of integrins and use thereof

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United States of America Patent

PATENT NO 8927534
APP PUB NO 20090104116A1
SERIAL NO

12162798

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Abstract

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The present invention is related to a compound of formula (I), wherein A is a nonaromatic heterocyclic ring, Ar is either absent or phenylene; Ψ is a radical of formula (II), R2 is a hydrophobic moiety; and G is a radical containing one or more moieties selected from the group consisting of NH, OH and a basic moiety. The compounds are inhibitors of integrins, especially antagonists of the fibronectin receptor alpha5beta1, useful as anti-angiogenic agents.

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Patent Owner(s)

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JERINI AGBERLIN GERMANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Christner-Albrecht, Claudia Berlin, DE 2 23
Hummel, Gerd Berlin, DE 22 178
Kalkhof, Holger Berlin, DE 2 23
Osterkamp, Frank Berlin, DE 31 175
Reineke, Ulrich Berlin, DE 34 219
Scharn, Dirk Berlin, DE 20 96
Stragies, Roland Berlin, DE 11 94
Vossmeyer, Doerte Berlin, DE 2 23
Zahn, Grit Berlin, DE 4 73
Zischinsky, Gunther Berlin, DE 13 71

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