Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof

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United States of America Patent

PATENT NO 8920835
APP PUB NO 20120301547A1
SERIAL NO

13512402

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Abstract

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A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

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Patent Owner(s)

Patent OwnerAddress
SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES201203 555 ZHANGJIANG ROAD ZHANGJIANG PUDONG NEW AREA SHANGHAI SHANGHAI CITY SHANGHAI CITY 201203
QILU PHARMACEUTICAL CO LTDXINLUO AVENUE HIGH TECH ZONE OF JI'NAN CITY SHANDONG PROVINCE NO 317 250100 JINAN CITY A FOLK ART FORM POPULAR IN SHANDONG 250100

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gan, Li Shanghai, CN 15 66
Gan, Yong Shanghai, CN 22 41
Wang, Jingyi Jinan, CN 99 160
Yang, Qingmin Jinan, CN 9 49
Zhang, Xinxin Shanghai, CN 80 220
Zheng, Xiaoqing Jinan, CN 71 592
Zhu, Chunliu Shanghai, CN 5 31

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