Screening for solid forms by ultrasound crystallization and cocrystallization using ultrasound
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United States of America Patent
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Dec 30, 2014
Grant Date -
Oct 13, 2011
app pub date -
Sep 22, 2010
filing date -
Mar 12, 2004
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Abstract
The present disclosure relates to crystallizing a chemical substance(s) using ultrasound. Methods are provided for screening a chemical substance according to its solid forms by using ultrasound to generate new or unusual solid forms. Methods are also provided for crystallizing a chemical substance by novel techniques that include sonication. The present disclosure also relates to cocrystallization using ultrasound. Methods are provided for preparing cocrystals of an active agent and a guest by sonicating and crystallizing. Methods are also provided for screening a sample according to solid state phases (such as cocrystals and salts) and include generating a cocrystal from the sample using ultrasound.
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