Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
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United States of America Patent
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Dec 16, 2014
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Nov 17, 2004
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May 23, 2000
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Abstract
A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
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