Very low-dosed solid oral dosage forms for HRT

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United States of America Patent

PATENT NO 8906890
SERIAL NO

13087701

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Abstract

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The present invention relates to a very low-dosed dosage form for hormone replacement therapy (HRT). More particularly, the present invention concerns a solid oral dosage form comprising about 0.5 mg estradiol and about 0.25 mg drospirenone, and at least one pharmaceutically acceptable excipient. Despite the very low E2 and DRSP doses it has surprisingly been found that a high proportion of the women suffering from moderate to severe hot flushes actually respond to this treatment. Accordingly, the dosage form of the invention may be used as maintenance HRT or may be used already when HRT is initiated.

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Patent Owner(s)

Patent OwnerAddress
BAYER INTELLECTUAL PROPERTY GMBHGERMANY MONHEIM BAVARIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gude, Kerstin Birkenwerder, DE 4 0
Mletzko, Stephan Berlin, DE 7 65
Schurmann, Rolf Teltow, DE 3 59

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